Voditelj:
prof.dr.sc. Dora Višnjić
Zavod za fiziologiju i imunologiju
Hrvatski institut za istraživanje mozga
Medicinski fakultet Sveučilišta u Zagrebu
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Suradnici:
prof.dr.sc. Hrvoje Banfić
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doc.dr.sc. Vesna Lukinović-Škudar
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doc.dr.sc. Vladiana Crljen
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Hrvoje Lalić, dr.med.
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Vilma Dembitz, dr.med.
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Dunja Tanković, laboratorijski tehničar
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Istraživački interes ovog laboratorija je proučavanje signalnih putova tijekom proliferacije i diferencijacije leukemijskih staničnih linija.

Link na aktualni projekt koji se provodi u nasem laboratoriju autofagija.hiim.hr

Head:
Professor Dora Višnjić,
Department of physiology and immunology
Croatian Insitute for Brain Research
School of Medicine University of Zagreb
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Associates:
Professor Hrvoje Banfić
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Assistant Professor Vesna Lukinović-Škudar
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Assistant Professor Vladiana Crljen
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Hrvoje Lalić, MD, PhD
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Vilma Dembitz, MD
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Dunja Tanković, lab. tech.
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Scientific scope of this laboratory is the study of signalling pathways during proliferation and differentiation of leukemic cells.

Link to the project currently ongoing at our laboratory autofagija.hiim.hr

• Lalic H, Dembitz V, Lukinovic-Skudar V, Banfic H, Visnjic D.5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells.Leuk Lymphoma. 2014 doi:10.3109/10428194.2013.876633
• Banfic H, Bedalov A, York JD, Visnjic D. Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. J Biol Chem 288:1717-1725, 2013.
• Lalic H, Lukinovic-Skudar V, Banfic H, Visnjic D. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma 53:2253-2261, 2012.
• Mise J, Dembitz V, Banfic H, Visnjic D. Combined Inhibition of PI3K and mTOR Exerts Synergistic Antiproliferative Effect, but Diminishes Differentiative Properties of Rapamycin in Acute Myeloid Leukemia Cells. Pathol Oncol Res. 17:645-656, 2011.
• Matkovic K, Lukinovic-Skudar V, Banfic H, Visnjic D. The activity of extracellular signal-regulated kinase is required during G2/M phase before metaphase-anaphase transition in synchronized leukemia cell lines. Int J Hematol 89:159-166, 2009.
• Banfic H, Visnjic D, Mise N, Balakrishnan S, Deplano S, Korchev YE, Domin J. Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus. Biochem J. 422:53-60, 2009.
• Visnjic D, Banfic H. Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase. Pflugers Arch. 455:19-30, 2007.
• Lukinovic-Skudar V, Matkovic K, Banfic H, Visnjic D. Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G1 phase of the cell cycle. Biochim Biophys Acta. 1771:514-21, 2007.
• Matkovic K, Brugnoli F, Bertagnolo V, Banfic H, Visnjic D. The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells. Leukemia. 20:941-51, 2006.
• Lukinovic-Skudar V, Donlagic L, Banfíc H, Visnjic D. Nuclear phospholipase C-β1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells. Biochim Biophys Acta. 1733:148-56, 2005.
• Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood. 103:3258-64, 2004.
• Visnjic D, Curic J, Crljen V, Batinic D, Volinia S, Banfic H. Nuclear phosphoinositide 3-kinase C2β activation during G2/M phase of the cell cycle in HL-60 cells. Biochim Biophys Acta. 1631:61-71, 2003.
• Visnjic D, Crljen V, Curic J, Batinic D, Volinia S, Banfic H. The activation of nuclear phosphoinositide 3-kinase C2β in all-trans-retinoic acid-differentiated HL-60 cells. FEBS Lett. 529:268-74, 2002.
• Visnjic D, Kalajzic I, Gronowicz G, Aguila HL, Clark SH, Lichtler AC, Rowe DW. Conditional ablation of the osteoblast lineage in Col2.3Δtk transgenic mice. J Bone Miner Res. 16:2222-31, 2001.
• Dacic S, Kalajzic I, Visnjic D, Lichtler AC, Rowe DW. Col1a1-driven transgenic markers of osteoblast lineage progression. J Bone Miner Res. 16:1228-36, 2001.
• Visnjic D, Batinic D, Banfic H. Different roles of protein kinase C α and δ isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells. Biochem J. 344:921-8, 1999.
• Visnjic D, Batinic D, Banfic H. Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line. Blood. 89:81-91, 1997.
• Visnjic D, Batinić D, Lasić Z, Knotek M, Marusić M, Banfić H. Phorbol 12-myristate 13-acetate-mediated signalling in murine bone marrow cells. Biochem J. 310:163-70, 1995.