Voditelj:
Prof. dr. sc. Goran Šimić, dr. med.
Redoviti profesor neuroznanosti i anatomije
Predstojnik Zavoda za neuroznanost i Pročelnik Vijeća predmeta "Temelji neuroznanosti"
Zavod za neuroznanost, Hrvatski institut za istraživanje mozga
Medicinski fakultet Sveučilišta u Zagrebu
Šalata 12, 10000 Zagreb, Republika Hrvatska
Translational Neuroscience, glavni i odgovorni urednik http://www.degruyter.com/view/j/tnsci
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Suradnici:
Mirjana Babić, mag.biol.mol.
Zavod za neuroznanost, Hrvatski institut za istraživanje mozga
Medicinski fakultet Sveučilišta u Zagrebu
Šalata 12, 10000 Zagreb, Republika Hrvatska
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Istraživački interesi:
Istraživački interesi Laboratorija za razvojnu neuropatologiju usmjereni su na proučavanje: (1) mehanizama starenja i neurodegeneracije, napose selektivne vulnerabilnosti neurona u Alzheimerovoj bolesti, (2) etiopatogeneze spinalnih mišićnih atrofija i drugih razvojnih neuromišićnih bolesti, te (3) ustrojstva, djelovanja i poremećaja moždane kore, te njezine kemijske neuroanatomije. U posljednjih nekoliko godina je glavni cilj laboratorija bilo određivanje bioloških biljega Alzheimerove bolesti iz cerebrospinalne tekućine i plazme, te usporedba dobivenih vrijednosti s rezultatima komplementarnih dijagnostičkih postupaka neuropsihološkog testiranja, evociranih potencijala, genetičkih i neuroslikovnih bioloških biljega (http://alzbiotrack.hiim.hr/). U našem laboratoriju također odnedavno rabimo inovativni neinvazivni test skrivenog objekta kojim se procjenjuje poremećaj prostorne orijentacije kao jedan od najranijih znakova Alzheimerove bolesti. Pored određivanja polimorfizama gena povezanih sa sporadičnom Alzheimerovom bolešću s kasnim početkom, te njihove uloge u patogenezi bolesti, naš je krajnji cilj postavljanje pouzdane rane dijagnoze bolesti u pacijenata s blagim spoznajnim poremećajem, ali također i njezino diferencijalno-dijagnostičko razlikovanje od drugih primarnih uzroka demencije. Koristeći nekoliko različitih kultura živčanih stanica istražujemo i učinke potencijalno neuroprotektivnih spojeva na patološke promjene tipične za Alzheimerovu bolest, posebice fosforilaciju tau proteina. Usporedno s navedenim istraživanjima demencije, pomoću mikropostrojbene analize i konfokalne imunofluorescencijske mikroskopije nedavno smo započeli istraživati i promjene izraženosti gena te podvrsti dopaminergičkih receptora na postmortalnim uzorcima mozgova bolesnika sa shizofrenijom.
Projekti:
0108-1081870-1942 MZOŠ „Fosforilacija tau proteina u razvitku I Alzheimerovoj bolesti“
09/16 HRZZ „Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u sporadičnoj Alzheimerovoj bolesti“
CMST COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting andmodulating complex function in the monoaminergic systems of the brain”
Znanstvena suradnja:
dr. Patrick R. Hof, prof., Mount Sinai School of Medicine, New York, Sjedinjene Američke Države
dr. Adrian Danek, prof., Groβhadern Klinika, Ludwig-Maximilian Sveučilište, München, Njemačka
dr. Glenn E. Morris, prof., Robert Jones and Agnes Hunt Ortopedic Hospital, Oswestry, Keele Sveučilište, Ujedinjeno Kraljevstvo
Rohan de Silva, DPhil, University College London, Ujedinjeno Kraljevstvo
Andrea Diana, PhD, Zavod za biomedicinske znanosti Sveučilišta Cagliari, Italija
Head:
Goran Šimić, MD, PhD
Professor of Neuroscience and Anatomy
Chair, Department of Neuroscience
Croatian Institute for Brain Research
University of Zagreb Medical School
Šalata 12, HR-10000 Zagreb, Republic of Croatia
Translational Neuroscience, Editor-in-Chief and Managing Editor http://www.degruyter.com/view/j/tnsci
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Staff:
Mirjana Babić, mag.biol.mol.
Croatian Institute for Brain Research
University of Zagreb Medical School
Šalata 12, HR-10000 Zagreb, Croatia
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Research interests:
The research interests of the Laboratory for Developmental Neuropathology are centered on (1) the mechanisms of brain aging and neurodegeneration, especially the study of selective neuronal vulnerability in Alzheimer's disease, (2) the etiopathogenesis of spinal muscular atrophy and other developmental neuromuscular diseases, and (3) the structure, function, and disorders of the human cerebral cortex and its chemical neuroanatomy. In recent years the main objective of the laboratory was the determination of early Alzheimer's disease biomarkers in cerebrospinal fluid and plasma, in the context of complementary diagnostic modalities, such as neuropsychological testing, evoked potentials, and genetic and neuroimaging biomarkers (http://alzbiotrack.hiim.hr/). We are also using an innovative non-invasive hidden-goal task to detect spatial orientation impairment, one of the earliest signs of Alzheimer's disease. Besides identification of gene polymorphisms associated with late-onset, sporadic Alzheimer's disease, and their role in disease pathogenesis, our ultimate goal is to establish reliable early diagnosis of the disease in patients with mild cognitive impairment, and to differentiate it from other primary causes of dementia. We are also using several neuronal cell lines to investigate the effects of potentially neuroprotective compounds on typical Alzheimer's disease pathological changes, particularly tau phosphorylation. In parallel to these studies of dementia, by using microarray analysis and a panel of novel monoclonal antibodies for immunofluorescence confocal microscopy we have initiated studies of changes in gene expression and localization of dopaminergic receptor subtypes in brains of patients with schizophrenia.
Projects:
0108-1081870-1942 MZOŠ „Phosphorylation of tau proteins during development and Alzheimer’s disease”
09/16 CSF „ Detection and tracking of biological markers for early therapeutic intervention in sporadic Alzheimer’s disease “
CMST COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and
Scientific collaboration:
dr. Patrick R. Hof, prof., Mount Sinai School of Medicine, New York, NY, United States of America
dr. Adrian Danek, prof., Groβhadern Klinika, Ludwig-Maximilian University, München, Germany
dr. Glenn E. Morris, prof., Robert Jones and Agnes Hunt Ortopedic Hospital, Oswestry, Keele University, United Kingdom
Rohan de Silva, DPhil, University College London, United Kingdom
Andrea Diana, PhD, Department for Biomedical Sciences, Cagliari, Italy
- Šimić G, Mladinov M, Šešo-Šimić Đ, Jovanov-Milošević N, Islam A, Pajtak A, Barišić N, Sertić J, Lucassen PJ, Hof PR, Krušlin B (2008) Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy. Acta Neuropathol. 115: 313-326.
- Šimić G (2008) The pathogenesis of proximal autosomal recessive spinal muscular atrophy. Acta Neuropathol. 116: 223-234.
- Šimić G, Stanić G, Mladinov M, Jovanov-Milošević N, Kostović I, Hof PR (2009) Does Alzheimer’s disease begin in the brainstem? Neuropathol. Appl. Neurobiol. 35: 532-554.
- Rhaganti M-A, Šimić G, Watson S, Stimpson CD, Hof PR, Sherwood CC (2011) Comparative analysis of the nucleus basalis of Meynert in primates. Neuroscience 185: 1-15.
- Petanjek Z, Judaš M, Šimić G, Rašin MR, Uylings HBM, Rakic P, Kostović I (2011) Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc. Natl. Acad. Sci. 108: 13281-13286.
- Boban M, Malojčić B, Mimica N, Vuković S, Zrilić I, Hof PR, Šimić G (2012) The reliability and validity of the mini-mental state examination in the elderly Croatian population. Dement. Geriatr. Cogn. Disord. 33: 385-392.
- Jovanov Milošević N, Petrović D, Sedmak G, Vukšić M, Hof PR, Šimić G (2012) Human fetal tau protein isoform: possibilities for Alzheimer's disease treatment. Int. J Biochem. Cell Biol. 44: 1290-1294.
- Babić M, Švob Štrac D, Mück-Šeler D, Pivac N, Stanić G, Hof PR, Šimić G (2014) Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer’s disease. Croat. Med. J 55: 347-365.
- Šimić G, Babić M, Borovečki F, Hof PR (2014) Early failure of the default-mode network and the pathogenesis of Alzheimer's disease. CNS Neurosci. Ther. 20: 692-698.
- Šimić G, Hof PR (2015) In search of the definitive Brodmann's map of cortical areas in human. J. Comp. Neurol. 523: 5-14.
