Voditeljica laboratorija:
Doc.dr.sc. Željka Krsnik
Suradnici:
Prof.dr.sc. Miloš Judaš,
prof.dr.sc. Mario Vukšić,
akademik Ivica Kostović,
Doc.dr.sc. Goran Sedmak,
Ana Jagušt
Inozemni suradnici:
Prof.dr.sc. Paško Rakić, Yale University,
Prof. Mladen-Roko Rašin, Rutgers University
U laboratoriju za neurorazvojnu analizu RNA bavimo se vremensko-prostornom analizom transkriptoma ljudskog mozga, u sklopu nekoliko domaćih projekata i inozemnih kolaboracija, koristeći rezultate mikročip tehnologije, in situ hibridizacije, imunocitokemije, te neuroanatomske nalaze.
Head:
Željka Krsnik, PhD, Assistant Professor
Collaborators:
Prof. Miloš Judaš,
Prof. Mario Vukšić,
Prof. Ivica Kostović,
Prof. Goran Sedmak
Foreign Collaborators:
Prof. Paško Rakić (Yale University),
Prof. Mladen-Roko Rašin (Rutgers University)
Associate:
Ana Jagust
Research interest:
Focus of our research is spatio-temporal analysis of human brain transcriptome during development using different approaches, such as Affymetrix GeneChip Human Exon Array, in situ hybridization of selected candidate gene coupled to immunohistochemistry or immunoflurescence.
Funds:
IBRO RHF (2014/15): “Perinatal reorganization of the connectivity elements in the marginal zone of the human neocortex”: Dr. Ž. Krsnik
Foundation of Croatian Academy of Science and Art (2014/15) “Digitalization of Zagreb Brain Collection”: Dr. Ž.Krsnik
WWN/SFN Collaborative Research Program (2014/15): “Neurosteroids as therapeutic opportunities in ischemic brain in ischemic brain injury”: collaborative research program between three institutions: Dr. J. Zlatkovic, Dr. D. Švob-Štrac & Dr. Ž.Krsnik
Croatian Science Foundation (2012/15): “Development of cell-type specific expression of human transcriptome in language and mirror neuron system related cortical network” (Prof. Miloš Judaš, P.I.)
Croatian Science Foundation (2014/18): (Prof. Mario Vukšić, P.I.) „Histological, MRI, and gene expression analysis of the reorganizational processes in the mdial (limbic) wall of developing human cerebrum“
- Kostović I, Sedmak G, Vukšić M, Judaš M. (2015) The relevance of human fetal subplate zone for developmental neuropathology of neuronal migration disorders and cortical dysplasia. CNS Neurosci Ther. 21(2):74-82
- Kang H., Kawasawa Y., Cheng F., Zhu Y., Xu, X., Li M., Sousa A., Pletikos M., Meyer K., Sedmak G., Guennel T., Shin Y., Johnson M.B., Krsnik Z., Mayer S., Fertuzinhos S., Umlauf S., Lisgo S.N., Vortmeyer A., Weinberger D., Mane, S., Hyde T.M., Huttner A., Reimers M., Kleinmann J., Sestan N. (2011): Spatiotemporal transcriptome of the human brain. Nature 478(7370):483-9.
- Johnson MB, Kawasawa YI, Mason CE, Krsnik Z, Coppola G, Bogdanovic D, Geschwind DH, Mane SM, State M, Sestan N (2009) Genetic complexity of human brain development and evolution revealed through global exon usage analysis. Neuron 62: 494-509.
- Fertuzinhos S, Krsnik Z, Kawasawa YI, Rasin MR, Kwan KY, Chen JG, Judas M, Hayashi M., Sestan N (2009) Selective loss of cortical interneurons in human holoprosencephaly with striatal hypoplasia. Cerebral Cortex 19: 2196-207
- Stillman A*, Krsnik Z*, Sun J, Rasin MR, State M, Sestan N, Louvi A (2009) Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. Journal of Comparative Neurology 513: 21- 37
- Kwan KY, Lam MM, Krsnik Z, Kawasawa YI, Lefebvre V, Sestan N. (2008) SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. PNAS 105: 16021-6
