Životopis: Ivica Kostović

CURRICULUM VITAE September, 2016

Ivica Kostović, Professor Emeritus; MD, DSc

PERSONAL:
Date and place of birth: June 7, 1943, Zagreb, Croatia
Nationality: Croatian
Marital status: Married, 2 children
Home Address: Pantovčak 162, 10000 Zagreb, Croatia

RESEARCH INTEREST:
Human developmental neurobiology and neuroanatomy, Development of cortical circuitry: synaptogenesis, axonal pathways, dendrites; Transient patterns of cortical organisation, Life-long development of human cortex, Correlation between cortical histogenesis and MR imaging, Perinatal brain lesions

EDUCATION:
1962-1967 School of Medicine, University of Zagreb (MD)
1968-1971 Faculty of Natural Sciences, University of Zagreb (MSc, Neurobiology)
1972 School of Medicine, University of Zagreb (DSc, Neuroanatomy)
1972-1974 The Johns Hopkins University School of Medicine, U.S.A. (Postdoctoral Fellow)

SPECIALIZATION & TRAINING:
1972-1974 Fogarty and Fullbright Fellowship, The Johns Hopkins University, USA
1976 Department of Neuroscience, Harvard University School of Medicine, USA
1979-1990 Regular study visits (consultant for Human Neuroanatomy), Yale University School
of Medicine, USA
1990-1991 Spinoza Visiting Professor, The Netherlands Institute for Brain Research, Amsterdam, The Netherlands

ACADEMIC APPOINTMENTS:
1968 Assistant in Anatomy, School of Medicine, University of Zagreb
1972-1974 Postdoctoral fellowship in Neuroanatomy and Neurology at The Johns Hopkins University School of Medicine, Baltimore, USA (Fogarty International Fellow & Fullbright Fellow) with drs Hendrik Van der Loos and Mark E. Molliver.
1975 Assistant Professor of Anatomy, School of Medicine, University of Zagreb
1976 Visiting Assistant Professor of Neuropathology, Department of Neuroscience, Harvard University School of Medicine, Boston, USA (with drs Pasko Rakic and Richard Sidman)
1978 Associate Professor of Anatomy, School of Medicine, University of Zagreb
1980 Professor of Anatomy, School of Medicine, University of Zagreb
1987 Head, Section of Neuroanatomy, Department of Anatomy, School of Medicine, University of Zagreb
1990 Chairman, Department of Anatomy, School of Medicine, University of Zagreb
1990-1991 Vice-Dean for Science, School of Medicine, University of Zagreb
1992-1993 Dean, School of Medicine, University of Zagreb
1991-1997 Chief Coordinator, Croatian Institute for Brain Research, School of Medicine, University of Zagreb
1991 Spinoza Professor, University of Amsterdam, The Netherlands
1998-2013 Professor of Neuroscience & Anatomy (re-elected), Department of Neuroscience, Croatian Institute for Brain Research, School of Medicine, University of Zagreb
2000-2013 Director, Croatian Institute for Brain Research
2013-present Honorary Director, Croatian Institute for Brain Research
2014-present Professor Emeritus, University of Zagreb (elected by University Senate)

PRINCIPAL INVESTIGATOR ON THE FOLLOWING PROJECTS:
1982-1985 U.S. Joint Board Project 02-091-N «Histogenesis and differentiation of the cerebral cortex in the human fetus» (P.I. Dr. I. Kostović; U.S. Collaborator Dr. Pasko Rakic)
1986-1989 U.S. Joint Board Project PN 698 «Perinatal development of the human frontal lobe» (P.I. Dr. I. Kostović; U.S. Collaborator Dr. Pasko Rakic)
1990-1992 «Developmental neurobiology of schizophrenia» - the joint project of the Section of Neuroanatomy (School of Medicine Zagreb – I. Kostović) and Section of Neurobiology (Yale University School of Medicine – Dr. Patricia S. Goldman-Rakic)
1990-present «Perinatal reorganization of the cortical circuitry during formation of cerebral convolutions in the human frontal lobe» - collaborative project with The Netherlands Institute for Brain Research, Amsterdam (P.I. Dr. I. Kostović, Dutch collaborators Dr. H.B.M. Uylings and Dr. D.F. Swaab)
1997-present Research program of the Croatian Institute for Brain Research “Neurobiology of cognitive development and cognitive disorders”, continued since 2006 as NEUROKOD program “Neurodevelopmental Basis of Cognitive, Mental and Neurological Disorders“ joining 27 projects
2007- 2010 Head coordinator of project „Neuroimaging, neurogenomics and pharmacogenomics of the frontal lobe connectivity: normal development and abnormalities in developmental and cognitive disorders“(Research Co-operability Program - Crossing border project, Unity through Knowledge Fund)
2015-present Principal Investigator, project funded by National Science Foundation “Subplate zone of the human brain: unsolved problems”
2015-present Scientific Coordinator and Group Leader in Centre of Excellence “Croatian Institute for Brain Research - Centre for basic, clinical and translational neuroscience”

TEACHING ACTIVITIES:
More than 30 years of teaching experience in the field of Human Anatomy, Human Developmental Neuroanatomy, and Developmental Neuroscience. The founder of the first interdisciplinary course «Fundamentals of Neuroscience» at the School of Medicine, University of Zagreb, and principal teacher on several postgraduate neuroscience courses. Invited lecturer on several leading universities (Yale University, Harvard University, The Johns Hopkins University, University of Amsterdam, Karolinska Institute). The founder of PhD Program in Neuroscience at School of Medicine, University of Zagreb.

HONOURS AND AWARDS:
Medical Academy of Croatia (Vice-President in two terms)
Highest Award for Science in Republic of Croatia – Rugjer Boskovic Award (1990)
Spinoza Professor, University of Amsterdam (1991)
Medal of European Union for Humanitarian Work
The Flag of the United States of America (July 7, 1994)
Castang Lecture (2007)
National Science Award for Biomedicine and Health - Award for Lifetime Achievement (Croatia) 2009
Academia Europaea, Member
Croatian Academy of Arts and Sciences, Member

HONORARY DEGREES:
Doctor Honoris Causa, University of Osijek

PUBLIC SERVICE:
1993-1995 Deputy Prime Minister for Public Services, Republic of Croatia
1995-1998 Minister of Science & Technology, Republic of Croatia
2000 - 2003 Elected Representative and Deputy Speaker, House of Representatives, Croatian Parliament
2010-2013 National Science Foundation, President of the Board
2014-present National Council for Science, Higher Education and Technological Development, Member

MEMBERSHIP:
Society for Neuroscience; Federation of European Neuroscience Societies (FENS); International Brain Research Organization (IBRO); Croatian Society for Neuroscience (CSFN) – President; Academia Europaea, European Dana Alliance for the Brain (EDAB), Cajal Club

EDITORIAL BOARDS:
Cerebral Cortex
Translational Neuroscience

ADVISORY ACTIVITIES:
US National Committee for IBRO
NeuroDevNet (Canada), Board Member
European Research Council (Panel Member for LS5, Neurosciences and Neural
Disorders)
School of Medicine, University of Zagreb, Dean's Advisor for Science

GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS WHO DEVELOPED INTERNATIONAL CAREER OR BECAME HEAD OF DEPARTMENT.
Ladislav Mrzljak, MD, PhD; Neuropharmacology, Translational Biology, CHDI Management, Inc. Director
Miloš Judaš- MD, PhD, Professor of Neuroscience & Anatomy , Croatian Institute for Brain Research, Director; National Center of Excellence in Basic, Clinical & Translational Neuroscience , Director; University of Zagreb, Vice-Rector for Science & International Relations
Ivana Dellale, MD, PhD, Associate Professor, Boston University School of Medicine, Pathology and Laboratory Medicine
Neven Henigsberg,. MD, PhD, Associate Professor, Head of the Institute for Psychiatric Research, Department of General and Forensic Psychiatry Clinical Psychophysiology the Psychiatric hospital, Zagreb
Zdravko Petanjek, MD, PhD, Professor of Neuroscience & Anatomy, Head of Institute of Anatomy Drago Perović, School of Medicine, University of Zagreb
Goran Šimić, MD, PhD, Professor of Neuroscience & Anatomy, Head of Department of Neuroscience, School of Medicine, University of Zagreb
Nataša Jovanov Milošević, DVM, PhD, Associate Professor, Associate Provost for Animal Research and Resources and Chair of the Institutional Animal Care and Use Committee, School of Medicine, University of Zagreb
Željka Krsnik, MS, PhD, Assistant professor, Croatian Institute for Brain Research, School of Medicine, University of Zagreb- Director Assistant for Management and PR
Mario Vukšić, MD, PhD, Associate Professor of Neuroscience & Anatomy - Coordinator of PhD Programme in Neuroscience, Croatian Institute for Brain Research, School of Medicine, University of Zagreb
Marija Heffer, MD, PhD, Professor; Head of Department of Medical Biology and Genetics; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek
Darko Chudy, MD, PhD – Assistant Professor; Head of Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb
Marko Radoš, MD, PhD, Associate professor, Head of Clinical Institute for Diagnostic and Interventional Radiology, Clinical Hospital Centre Zagreb
Vesna Benjak, MD, PhD, Head of the Department of Neonatology and Intensive Care, Clinical Hospital Centre Zagreb
Nenad Bogdanović, MD, PhD, Professor, Department of Geriatric Medicine, University of Oslo
Mladen Roko Rašin, MD, PhD; Assistant Professor; Department of Neuroscience and Cell Biology, Rutgers Robert wood Johnson Medical School, New Jersey
Krešimir Letinić, MD, PhD, Board Director and Chief Business Officer in Medikly, a Board director in Wildflower Health

ORGANISER OF INTERNATIONAL SYMPOSIUMS AND COURSES:

  • 3rd International Symposium on Normal and Abnormal Development of the Human Fetal Brain, Croatian Society for Neuroscience, Zagreb, Croatia, 2003
  • 1st IBRO/FENS Summer School «Development and Plasticity of the Human Cerebral Cortex», Croatian Society for Neuroscience, Dubrovnik - Zagreb, 2004
  • 2nd IBRO/FENS Summer School «Development and Plasticity of the Human Cerebral Cortex», Croatian Society for Neuroscience, Zadar - Zagreb, 2005
  • 5 Congresses of Croatian Society for Neuroscience

SELECTED INVITED LECTURES:

  • Symposium “The acting brain”, SISSA, Trst, 21-22 Sep 2000
  • 1st International Symposium on Normal and Abnormal Development of the Human Fetal Brain, Hong-Kong, 18-21. 03. 2001.
  • International Conference “Neurobiology in Eastern and Western Europe”, SISSA, Trieste, 01-03 Dec 2001
  • 2nd Symposium on Normal and Abnormal Development of the Human Fetal Brain, Rostock, 24-25 May 2002
  • 3rd International Symposium on Normal and Abnormal Development of the Human Fetal Brain, Croatian Society for Neuroscience, Zagreb, June 13-15, 2003
  • 4th Graz Symposium on Developmental Neurology”, Graz, 22- 24 May 2003
  • Research Course Series in Human Neuroanatomy and Neurodegeneration, Karolinska Institute, Stockholm, 12-15 Apr 2004
  • Fetal MRI Course”, Vienna, 12-16 May 2004
  • 1st IBRO/FENS Summer School «Development and Plasticity of the Human Cerebral Cortex», Croatian Society for Neuroscience, Dubrovnik-Zagreb, 24 Sep – 4 Oct 2003.
  • 1st International Symposium on Fetal Behaviour”, World Association of Perinatal Medicine Barcelona , 18- 19 Feb 2005
  • Research Course Series in Human Neuroanatomy and Neurodegeneration, Karolinska institute, Stockholm, 06- 10 Mar 2005.
  • May Symposium Helsinki – “Development of cerebral cortex”, Helsinki, 24- 29 May 2005
  • NATO Workshop – «NOVEL APPROACHES TO THE DIAGNOSIS OF PTSD», Dubrovnik, 13- 16 Jun 2005
  • 7th World Congress of Perinatal Medicine”, Zagreb, 21- 24 Sep 2005.
  • 2nd IBRO/FENS Summer School «Development and Plasticity of the Human Cerebral Cortex», Croatian Society for Neuroscience, Zadar - Zagreb 24 Sep -1 Oct 2005
  • Sinapsa – Neuroscience Symposium 2005, Ljubljana, 19- 21 Nov 2005
  • Int. Professional Meeting and Workshop for Diagnostic Imaging by Ultrasound – “Early Brain Lesi¬on”, Maribor, 09- 11 Dec 2005
  • Castang lecture, EACD’s 19th Annual Meeting, Groningen, 12-13 Jun 2007
  • Symposium Mark Molliver, Johns Hopkins, Baltimore, 22 Jun 2007
  • 7th International Congress on Early Brain Damage, Bled, 23-26 Apr 2008
  • 2. Fetal MRI Congress, Vienna, 16-17 May 2008
  • Summer Institute in Cognitive Neuroscience, Lake Tahoe, California, 23-24 Jun 2008
  • Symposium „Molecular view of a synapse and its surroundings in physiological and pathological neuronal plasticity”, Wierzba (Poland), 01-05 Sep 2009
  • Cajal Club/Italian Neuroscience Society, Pavia/ Milano, 29 Sep -02 Oct 2009
  • Ipokrates Seminar, Athens, 23-27 Nov 2009
  • Symposium „Development of the Human Cortex“ (Winter meeting of the Anatomical Society of Gre¬at Britain and Ireland), Oxfordu, 05- 07 Jan 2010.
  • 3. Fetal MRI Congress, Vienna, 13– 15 May 2010
  • Ipokrates Seminar, Madrid, 03- 04 Jun 2010
  • Human Brain Mapping, Barcelona, 05 – 07 Jun 2010
  • State-of the –art lecture – 9th Congress of European Pediatric Neurology Society, Cavtat, 11 May 2011
  • FENS/SINAPSA, Ljubljana, 22-25 Sep 2011
  • From Ruđer Bošković to today: Contribution of Croatian Scientists to the World Scienti¬fic Heritage, Dubrovnik, 29 May-02 Jun 2011.
  • 17th Annual Meeting of the Organization for Human Brain Mapping, Quebec City, 26-30 Jun 2011
  • Prospects in Brain Development: from Cell to Environment, Amsterdam, 28. Oct 2011
  • Seminar in Hôpital des Enfants des HUG, Geneva, 26 Mar 2012
  • Congress of European Society of Magnetic Resonance in Neuropediatrics, Vienna, 4-8 Jun 2013
  • SINAPSA, Neuroscience Conference, Ljubljana, 27-29 Sep 2013
  • 0th International Congress „New developments in the assessment of early brain damage – 30 years later“, Bled, 25 Sep 2014
  • XII. AINR (Italian Association of Neuroradiology) Meeting of Pediatric Neuroradiology, Milano, 02 Oct 2014

SCIENTIFIC PUBLICATIONS:
Biometrics (August 2016): Citations: 6826; H-index 42; i10-index 80

IVICA KOSTOVIĆ: THE MOST SIGNIFICANT PUBLICATIONS

  1. Molliver ME, Kostović I, Van der Loos H (1973) The development of synapses in cerebral cortex of the human fetus. Brain Res 50:403-407
  2. Kostović I, Goldman-Rakic PS (1983) Transient cholinesterase staining in the mediodorsal nucleus of the thalamus and its connections in the developing human and monkey brain. J Comp Neurol 219:431-447.
  3. Kostović I, Rakic P (1984) Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining. J Neurosci 4:25-42.
  4. Kostović I (1986) Prenatal development of nucleus basalis complex and related fiber systems in man: a histochemical study. Neuroscience 17:1047-1077.
  5. Kostović I, Seress L, Mrzljak L, Judaš M (1989) Early onset of synapse formation in the human hippocampus: a correlation with Nissl-Golgi architectonics in 15- and 16.5-week-old fetuses. Neuroscience 30:105-116.
  6. Kostović I, Rakic P (1990) Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. J Comp Neurol 297:441-470.
  7. Kostović I, Petanjek Z, Judaš M (1993) Early areal differentiation of the human cerebral cortex: entorhinal area. Hippocampus 3:447-458.
  8. Kostović I, Judaš M (2002) Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants. The Anatomical Record 267:1-6.
  9. Kostović I, Judaš M, Radoš M, Hrabač P (2002) Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cerebral Cortex 12:536-544.
  10. Kostović I, Judaš M (2006) Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants, DCMN Developmental Medicine and Child Neurology vol 48: 388-393
  11. Kostovic I, Jovanov-Milosevic N (2006) The development of cerebral connections during the first 20-45 weeks’ gestation. Seminars in Fetal & Neonatal Medicine 11(6):415-22
  12. Petanjek Z, Judas M, Kostovic I, Uylings HB. (2007) Lifespan Alterations of Basal Dendritic Trees of Pyramidal Neurons in the Human Prefrontal Cortex: A Layer-Specific Pattern. Cereb Cortex.
  13. Kostovic I, Judas M (2007) Transient patterns of cortical lamination during prenatal life: Do they have implications for treatment?, Neuroscience and Biobehavioral Reviews 31(8): 1156-1168
  14. Ayoub AE, Kostovic I. (2009) New horizons for the subplate zone and its pioneering neurons. Cereb Cortex 19(8):1705-7
  15. Jovanov-Milosević N, Culjat M, Kostović I (2009). Growth of the human corpus callosum: modular and laminar morphogenetic zones. Front Neuroanat. 2009 Jun 9;3:6. doi: 10.3389/neuro.05.006.2009. eCollection 2009.
  16. Kostović I, Vasung L (2009) Insights from in vitro fetal magnetic resonance imaging of cerebral development. Semin Perinatol 33:220-33
  17. Kostović I, Judaš M, Sedmak G. (2010) Developmental history of the subplate zone, subplate neurons and interstitial white matter neurons: relevance for schizophrenia. Int J Dev Neurosci. 2011 May;29(3):193-205
  18. Kostovic I, Judas M (2010) The development of the subplaate and thalamocortical connections in the human fetal brain. Acta Paediatr. 99(8):1119-27
  19. Vasung L, Huang H, Jovanov-Milosevic N, Pletikos M, Mori S, Kostovic I (2010) Development of axonal pathways in the human fetal fronto-limbic brain: histochemical characterization and diffusion tensor imaging. J Anat 217:400-417
  20. Jovanov-Milosevic N, Petanjek Z, Petrovic D, Judas M, Kostovic I (2010) Morphology, molecular phenotypes and distribution of neurons in developing human corpus callosum. E J Neurosci 32: 1423-1432
  21. Vasung L, Jovanov-Milošević N, Pletikos M, Mori S, Judaš M, Kostović I. (2010) Prominent periventricular fibre system related to ganglionic eminence and striatum in the human fetal cerebrum. Brain Struct Funct. 2011 Jan;215(3-4):237-53. doi: 10.1007/s00429-010-0279-4. Epub 2010 Oct 15.
  22. Judaš M, Šimić G, Petanjek Z, Jovanov-Milošević N, Pletikos M, Vasung L, Vukšić M, Kostović I. (2011) The Zagreb Collection of human brains: a unique, versatile, but underexploited resource for the neuroscience community. Ann N Y Acad Sci.;1225 Suppl 1:E105-30. doi: 10.1111/j.1749-6632.2011.05993.x. Review.
  23. Petanjek Z, Judaš M, Šimić G, Rašin MR, Uylings HBM, Rakic P, Kostovic I: „Extraordinary neoteny of synaptic spines in the human prefrontal cortex“ , Proceedings of the National academy of Sciences 2011. 108(32):13281-6
  24. Huang H, Jeon T, Sedmak G, Pletikos M, Vasung L, Xu X, Yarowsky P, Richards LJ, Kostovic I, Sestan N, Mori S. (2012) Coupling Diffusion Imaging with Histological and Gene Expression Analysis to Examine the Dynamics of Cortical Areas across the Fetal Period of Human Brain Development. Cereb Cortex. 2013 Nov; 23(11):2620-31. doi: 10.1093/cercor/bhs241
  25. Petanjek Z, Kostović I.(2012) Epigenetic regulation of fetal brain development and neurocognitive outcome. Proc Natl Acad Sci U S A.; 109(28):11062-3. doi: 10.1073/pnas.1208085109.
  26. Kwan KY, Lam MM, Johnson MB, Dube U, Shim S, Rašin MR, Sousa AM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostović I, Judaš M, Sestan N. (2012) Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell. 11;149(4):899-911. doi: 10.1016/j.cell.2012.02.060.
  27. Kostović I, Jovanov-Milošević N, Radoš M, Sedmak G, Benjak V, Kostović-Srzentić M, Vasung L, Culjat M, Radoš M, Hüppi P, Judaš M. (2012) Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches. Brain Struct Funct. 2014 Jan;219(1):231-53. doi: 10.1007/s00429-012-0496-0
  28. Bregant T, Rados M, Vasung L, Derganc M, Evans AC, Neubauer D, Kostovic I.(2013) Region-specific reduction in brain volume in young adults with perinatal hypoxic-ischaemic encephalopathy. Eur J Paediatr Neurol. 2013 Nov;17(6):608-14. doi: 10.1016/j.ejpn.2013.05.005.
  29. Judaš M, Sedmak G, Kostović I.(2013) The significance of the subplate for evolution and developmental plasticity of the human brain. Front Hum Neurosci. 2013 Aug 2;7:423. doi: 10.3389/fnhum.2013.00423. eCollection 2013.
  30. Pogledic I, Kostovic I, Fallet-Bianco C, Adle-Biassette H, Gressen P, Verney C (2014) Involvement of the subplate zone in preterm infants with periventricular white matter injury. Brain Pathol. 2014 Mar;24(2):128-41. doi: 10.1111/bpa.12096. Epub 2014 Feb 18.
  31. Kostović I, Kostović-Srzentić M, Benjak V, Jovanov-Milošević N, Radoš M. (2014) Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates. Front Neurol. 2014 Jul 29;5:139. doi: 10.3389/fneur.2014.00139. eCollection 2014
  32. Kostović I, Sedmak G, Vukšić M, Judaš M.(2015) The Relevance of Human Fetal Subplate Zone for Developmental Neuropathology of Neuronal Migration Disorders and Cortical Dysplasia. CNS Neurosci Ther. 2015 Feb;21(2):74-82. doi: 10.1111/cns.12333
  33. Duque A, Krsnik Z, Kostović I, Rakic P. (2016) Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates.Proc Natl Acad Sci U S A. 2016 Aug 8. pii: 201610078. [Epub ahead of print]
  34. Vasung L, Lepage C, Radoš M, Pletikos M, Goldman JS, Richiardi J, Raguž M, Fischi-Gómez E, Karama S, Huppi PS, Evans AC, Kostovic I.(2016) Quantitative and Qualitative Analysis of Transient Fetal Compartments during Prenatal Human Brain Development. Front Neuroanat. 2016 Feb 24;10:11. doi: 10.3389/fnana.2016.00011. eCollection 2016.

ALL PUBLICATIONS:

  • Kostović I (1971) The terminal distribution of accessory optic fibres in the rat. Brain Res 31:202-206.
  • Krmpotić-Nemanić J, Kostović I, Rudan P, Nemanić D (1971) Morphological and histological changes responsible for drop of the nasal tip in advanced age. Acta Otolaryngol (Stockh) 71:278-281.
  • Krmpotić-Nemanić J, Nemanić D, Kostović I (1971) Alterserscheinungen im inneren Gehörgang und am Gehörnerven. Arch klin exp Ohren Kehlkopfheilk 199:468-473.
  • Krmpotić-Nemanić J, Nemanić D, Kostović I (1972) Macroscopical and microscopical changes in the bottom of the internal auditory meatus. Acta Otolaryngol 73:254-258.
  • Krmpotić-Nemanić J, Kostović I, Nemanić D (1972) The macroscopical and microscopical aging changes of the internal auditory meatus and its consequences on the auditory nerve and vessels. Minerva Otolaryngol 22:192-195.
  • Krmpotić-Nemanić J, Nemanić D, Kostović I (1973) Weiterer Beitrag zur Aetiologie der Presbyacusis. Acta Otolaryngol 75:211-215.
  • Molliver ME, Kostović I, Van der Loos H (1973) The development of synapses in cerebral cortex of the human fetus. Brain Res 50:403-407.
  • Kostović I, Krmpotić-Nemanić J (1976) Early prenatal ontogenesis of the neuronal connections in the interhemispheric cortex of the human gyrus cinguli. Verh Anat Ges 70:305-316.
  • Kostović-Knežević Lj, Kostović I, Krmpotić-Nemanić J, Kelović Z, Vuković B (1978) The cortical plate of the human neocortex during the early fetal period (at 31-65 mm CRL). Verh Anat Ges 72:721-723.
  • Kostović-Knežević Lj, Kostović I, Krmpotić-Nemanić J, Kelović Z (1979) Acetylcholinesterase (AChE) staining in the growing telencephalic structures of the human fetus. Verh Anat Ges 73:667-669.
  • Krmpotić-Nemanić J, Kostović I, Nemanić D, Kelović Z (1979) The laminar organization of the prospective auditory cortex in the human fetus (11-13.5 weeks of gestation). Acta Otolaryngol 87:241-246.
  • Kostović I, Kračun I, Kelović Z, Krmpotić-Nemanić J (1980) The development of "cholinergic" reaction in the septal area of the human fetus. Verh Anat Ges 74:729-732.
  • Krmpotić-Nemanić J, Kostović I, Kelović Z, Nema-nić D (1980) Development of acetylcholinesterase (AChE) staining in human fetal auditory cortex. Acta Otolaryngol 89:388-392.
  • Krmpotić-Nemanić J, Kostović I, Nemanić G, Kelović Z (1980) Entwicklung des prospektiven auditiven Cortex beim Menschen. Verh Anat Ges 74:413-416.
  • Kostović I, Rakic P (1980) Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. J Neurocytol 9:219-242.
  • Krmpotić-Nemanić J, Kostović I, Kelović Z, Nemanić D (1981) Cholinesterase-positive afferente Fasern im menschlichen fetalen auditiven Cortex. Verh Anat Ges 75:513-515.
  • Kostović I, Goldman-Rakic PS (1983) Transient cholinesterase staining in the mediodorsal nucleus of the thalamus and its connections in the developing human and monkey brain. J Comp Neurol 219:431-447.
  • Kračun I, Roesner H, Kostović I, Rahmann H (1983) Areal and laminar distribution of gangliosides in the fetal human neopallium at 28 weeks of gestation. Roux Arch Dev Biol 192:108- 112. CC
  • Krmpotić-Nemanić J, Kostović I, Kelović Z, Nemanić D, Mrzljak L (1983) Development of the human fetal auditory cortex: growth of afferent fibers. Acta Anat 116:69-73. CC
  • Krmpotić-Nemanić J, Kostović I, Nemanić D (1983) The development of medial geniculate body in man: changes in the cholinesterase (ChE) activity during fetal and perinatal life. Acta Otolaryngol 95:695-699.
  • Kostović I (1984) Development of cytoarchitectonic compartments in the putamen of the human fetal brain. Verh Anat Ges 78:301-302.
  • Kostović I, Rakic P (1984) Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining. J Neurosci 4:25-42.
  • Krmpotić-Nemanić J, Kostović I, Nemanić D (1984) Prenatal and perinatal development of radial cell columns in the human auditory cortex. Acta Otolaryngol 97:489-495.
  • Kostović I (1986) Prenatal development of nucleus basalis complex and related fiber systems in man: a histochemical study. Neuroscience 17:1047-1077. 3,456 CC
  • Nikolić I, Kostović I (1986) Development of the lateral amygdaloid nucleus in the human fetus: transient presence of discrete cytoarchitectonic units. Anat Embryol 174:355-360.
  • Kostović I, Judaš M, Bogdanović N (1987) Perinatal cytoarchitectonic development of the prospective "premotor" belt in man. Anat Anz - Verh Anat Ges 81:533-534.
  • Krmpotić-Nemanić J, Kostović I, Vidić Z, Nemanić D, Kostović-Knežević Lj (1987) Development of Cajal-Retzius cells in the human auditory cortex. Acta Otolaryngol 103:477-480.
  • Kostović I, Škavić J, Strinović D (1988) Acetylcholinesterase in the human frontal associative cortex during the period of cognitive development: early laminar shifts and late innervation of pyramidal neurons. Neurosci Lett 90:107-112.
  • Krmpotić-Nemanić J, Kostović I, Bogdanović N, Fučić A, Judaš M (1988) Cytoarchitectonic parameters of developmental capacity of the human associative auditory cortex during postnatal life. Acta Otolaryngol (Stockh) 105:463-466.
  • Lacković Z, Jakupčević M, Bunarević A, Damjanov I, Relja M, Kostović I (1988) Serotonin and norepinephrine in the spinal cord of man. Brain Research 443:199-203. CC
  • Mrzljak L, Uylings HBM, Kostović I, Van Eden CG (1988) Prenatal development of neurons in the human prefrontal cortex. I: A qualitative Golgi study. J Comp Neurol 271:355-386.
  • Uylings HBM, Mrzljak L, Kostović I, Van Eden CG (1988) Onstuimige groei van jonge hersenen. Natur & Techniek 56(5):414- 423.
  • Kostović I, Lukinović N, Judaš M, Bogdanović N, Mrzljak L, Zečević N, Kubat M (1989) Structural basis of the developmental plasticity in the human cerebral cortex: the role of the transient subplate zone. Metabol Brain Dis 4:17-23.
  • Kostović I, Seress L, Mrzljak L, Judaš M (1989) Early onset of synapse formation in the human hippocampus: a correlation with Nissl-Golgi architectonics in 15- and 16.5-week-old fetuses. Neuroscience 30:105-116.
  • Kostović I (1990) Structural and histochemical reorganization of the human prefrontal cortex during perinatal and postnatal life. Progr Brain Res 85:223-240.
  • Kostović I, Rakic P (1990) Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. J Comp Neurol 297:441-470.
  • Mrzljak L, Uylings HBM, Van Eden CG, Judaš M (1990) Neuronal development in human prefrontal cortex in prenatal and postnatal stages. Progr Brain Res 85:185-222.
  • Kostović I, Judaš M, Kostović-Knežević Lj, Šimić G, Delalle I, Chudy D, Šajin B, Petanjek Z (1991) Zagreb Research Collection of human brains for developmental neurobiologists and clinical neuroscientists. Int J Dev Biol 35:215-230.
  • Kostović I, Štefulj-Fučić A, Mrzljak L, Jukić S, Delalle I (1991) Prenatal and perinatal development of the somatostatin-immunoreactive neurons in the human prefrontal cortex. Neurosci Lett 124:153-156. CC
  • Kostović I, Judaš M (1991) Neuroscience in Yugoslavia. Trends Neurosci 14(5):171-175.
  • Marušić M, Hebrang A, Kostović I (1991) War in Yugoslavia (letter). British Medical Journal 303:997. CC
  • Kostović I, Marušić M (1991) Attacks on Croatia’s hospitals (letter). Lancet 338(8773):1018.
  • Mrzljak L, Uylings HBM, Kostović I, Van Eden CG (1992) Prenatal development of neurons in the human prefrontal cortex. II. A quantitative Golgi study. J Comp Neurol 316:485-496.
  • Kostović I, Petanjek Z, Judaš M (1993) Early areal differentiation of the human cerebral cortex: entorhinal area. Hippocampus 3:447-458.
  • Šestan N, Kostović I (1994) Histochemical localization of nitric oxide synthase in the CNS. Trends Neurosci 17(3):105-106.
  • Strinović D, Škavić J, Kostović I, Henigsberg N, Judaš M, Clark D (1994) Identification of war victims in Croatia. Med Sci Law 34(3):207-212. CC
  • Kostović I, Judaš M, Petanjek Z, Šimić G (1995) Ontogenesis of goal-directed behavior: anatomo-functional considerations. Internat J Psychophysiol 19:85-102.
  • Letinić K, Kostović I (1996) Transient patterns of calbindin-D28k expression in the developing striatum of man. Neurosci Lett 220:211-214. CC
  • Letinić K, Kostović I (1996) Transient neuronal population of the internal capsule in the developing human cerebrum. NeuroReport 7:2159-2162.
  • Letinić K, Kostović I (1997) Transient fetal structure, the gangliothalamic body, connects telencephalic germinal zone with all thalamic regions in the developing human brain. J Comp Neurol 381:1-23.
  • Šimić G, Kostović I, Winblad B, Bogdanović N (1997) Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J Comp Neurol 379:482-494. CC
  • Delalle I, Evers P, Kostović I, Uylings HBM (1997) Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development. J Comp Neurol 379:515-522.
  • Letinić K, Kostović I (1998) Postnatal development of calcium-binding proteins calbindin and parvalbumin in human visual cortex. Cereb Cortex 8(7):660-669.
  • Letinić K, Heffer-Lauc M, Rosner H, Kostović I (1998) C- pathway polysialogangliosides are transiently expressed in the human cerebrum during fetal development. Neuroscience 86(1):1-5.
  • Judaš M, Šestan N, Kostović I (1999) Nitrinergic neurons in the developing and adult human telencephalon: transient and permanent patterns of expression in comparison to other mammals. Microscopy Research and Technique 45(6):401-419.
  • Šimić G, Mrzljak L, Fučić A, Winblad B, Lovrić H, Kostović I (1999) Nucleus subputaminalis (Ayala): the still disregarded magnocellular component of the basal forebrain may be human specific and connected with the cortical speech area. Neuroscience 89(1):73-89.
  • Šimić G, Šešo-Šimić D, Lucassen PJ; Islam A, Krsnik Ž, Cviko A, Jelašić D, Barišić N, Winblad B, Kostović I, Krušlin B (2000) Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffman disease. J Neuropathol Exp Neurol 59(5):398-407.
  • Šimić G, Lucassen PJ, Krsnik Ž, Krušlin B, Kostović I, Winblad B, Bogdanović N (2000) NOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer’s disease. Exp Neurol 165(1):12-26.
  • Kostović I, Judaš M (2002) Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants. The Anatomical Record 267:1-6.
  • Kostović I, Judaš M, Radoš M, Hrabač P (2002) Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cerebral Cortex 12:536-544.
  • Kostović I, Rašin MR, Petanjek Z, Judaš M (2002) Morphological characteristics of the cells in the subcallosal zone (nucleus septohippocampalis) of the human fetus. Neuroembryology 1:97-104.
  • Kostović I, Judaš M (2002) The role of the subplate zone in the structural plasticity of the developing human cerebral cortex. Neuroembryology 1:145-153.
  • Chan WY, Kostovic I, Takashima S, Feldhaus C, Stoltenburg-Didinger G, Verney C, Yew D, Ulfig N (2002) Normal and abnormal development of the human cerebral cortex. Neuroembryology 1:78-90.
  • Vukšić M, Petanjek Z, Rašin MR, Kostović I (2002) Perinatal growth of prefrontal layer III pyramids in Down syndrome. Pediatr Neurol 27(1):36-38.
  • Judaš M, Rašin MR, Krušlin B, Kostović K, Jukić D, Petanjek Z, Kostović I (2003) Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly. Brain & Development 25:32-39.
  • Šimić G, Bexheti S, Kelović Z, Kos M, Grbić K, Hof PR, Kostović I (2005) Hemispheric asymmetry, modular variability and age-related changes in the human entorhinal cortex. Neuroscience 130 (4):911-925.
  • Kostović I, Jovanov-Milošević N, Krsnik Ž, Petanjek Z, Judaš M (2004) Laminar organization of the marginal zone in the human fetal cortex. Neuroembryology 3:19-26.
  • Judaš M, Radoš M, Jovanov-Milošević N, Hrabač P, Štern-Padovan R, Kostović I (2005) Structural, immunocytochemical, and MR imaging properties of periventricular crossroads of growing cortical pathways in preterm infants. AJNR Am J Neuroradiol 26:2671-2784.
  • Radoš M, Judaš M, Kostović I (2005) In vitro MRI of brain development, EJR European Journal of Radiology, 57:187-198
  • Boban M, Kostovic I, Simic G (2005) Nucleus subputaminalis: neglected part of basal nucleus of Meynert, , Brain 129: E42; author reply E43
  • Kostović I, Judaš M (2006) Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants, DCMN Developmental Medicine and Child Neurology vol 48: 388-393
  • Jovanov-Milosevic, Benjak V, Kostovic I (2006) Transient cellular structures in developing corpus callosum of the human brain, Coll. Antropol 30(2):375-381
  • Kostovic I, Jovanov-Milosevic N (2006) The development of cerebral connections during the first 20-45 weeks’ gestation. Seminars in Fetal & Neonatal Medicine 11(6):415-22
  • Petanjek Z, Judas M, Kostovic I, Uylings HB. (2007) Lifespan Alterations of Basal Dendritic Trees of Pyramidal Neurons in the Human Prefrontal Cortex: A Layer-Specific Pattern. Cereb Cortex. 18 (4):915-929.
  • Kostovic I, Judas M (2007) Transient patterns of cortical lamination during prenatal life: Do they have implications for treatment?, Neuroscience and Biobehavioral Reviews 31(8): 1156-1168
  • Kostovic I, Jovanov-Milosevic N (2008) Subplate zone of the human brain: historical perspective and new concepts, Coll. Antropol 32(2):3-8
  • Vuksic M, Rados M, Kostovic I (2008) Structural basis of developmental plasticity in the corticostratial system, Coll. Antropol 32(2): 155-159
  • Petanjek Z, Dujmović A, Kostović I, Esclapez M. (2008) Distinct origin of GABA-ergic neurons in forebrain of man, nonhuman primates and lower mammals. Coll Antropol 32 Suppl 1:9-17. Review.
  • Ayoub AE, Kostovic I. (2009) New horizons for the subplate zone and its pioneering neurons. Cereb Cortex 19(8):1705-7
  • Jovanov-Milosević N, Culjat M, Kostović I (2009). Growth of the human corpus callosum: modular and laminar morphogenetic zones. Front Neuroanat. 3:6. doi: 10.3389/neuro.05.006.2009.
  • Kostović I, Vasung L (2009) Insights from in vitro fetal magnetic resonance imaging of cerebral development. Semin Perinatol 33:220-33
  • Simic G, Stanić G, Mladinov M, Jovanov-Milosevic N, Kostovic I, Hof PR.(2009) Annotation - Does Alzheimer's disease begin in the brainstem? Neuropathol Appl Neurobiol. 35(6):532-54
  • Petanjek Z, Kostovic I, Esclapez M (2009) Primate-specific origins and migration of cortical GABAergic neurons. Front Neuroanat. 3:26
  • Kostovic I, Judas M (2010) The development of the subplaate and thalamocortical connections in the human fetal brain. Acta Paediatr. 99(8):1119-27
  • Defelipe J, Fields RD, Hof PR, Höistad M, Kostovic I, Meyer G, Rockland KS (2010) Cortical white matter: beyond the pale remarks; main conclusions and discussion. Front Neuroanat. 4:4
  • Cosic K, Popovic S, Kostovic I, Judas M (2010) Virtual reality aaptove stimulation of limbic networks in the mental readiness training. Stud Health Technol Inform 154:14-9
  • Vasung L, Huang H, Jovanov-Milosevic N, Pletikos M, Mori S, Kostovic I (2010) Development of axonal pathways in the human fetal fronto-limbic brain: histochemical characterization and diffusion tensor imaging. J Anat 217:400-417
  • Jovanov-Milosevic N, Petanjek Z, Petrovic D, Judas M, Kostovic I (2010) Morphology, moleculat phenotypes and distribution of neurons in developing human corpus callosum. E J Neurosci 32: 1423-1432
  • Kostović I, Judaš M, Sedmak G. (2010) Developmental history of the subplate zone, subplate neurons and interstitial white matter neurons: relevance for schizophrenia. Int J Dev Neurosci. 217 400-417
  • Vasung L, Jovanov-Milošević N, Pletikos M, Mori S, Judaš M, Kostović I. (2010) Prominent periventricular fibre system related to ganglionic eminence and striatum in the human fetal cerebrum. Brain Struct Funct. 2011 Jan; 215(3-4):237-53. doi: 10.1007/s00429-010-0279-4. Epub 2010 Oct 15.
  • Judas M, Petanjek Z, Kostović I. (2011) Jelena Krmpotić-Nemanić (1921-2008): contributions to human neuroanatomy. Coll Antropol. 35 Suppl 1:345-9.
  • Judaš M, Šimić G, Petanjek Z, Jovanov-Milošević N, Pletikos M, Vasung L, Vukšić M, Kostović I. (2011) The Zagreb Collection of human brains: a unique, versatile, but underexploited resource for the neuroscience community Ann N Y Acad Sci.;1225 Suppl 1:E105-30. doi: 10.1111/j.1749-6632.2011.05993.x. Review.
  • Petanjek Z, Judaš M, Šimić G, Rašin MR, Uylings HBM, Rakic P, Kostovic I: „Extraordinary neoteny of synaptic spines in the human prefrontal cortex“ , Proceedings of the National academy of Sciences 2011. 108(32):13281-6
  • Bregant T, Rados M, Derganc M, Neubauer D, Kostovic I. (2011) Pineal cysts - a benign consequence of mild hypoxia in a near-term brain? Neuro Endocrinol Lett. 2011;32(5):663-6.
  • Huang H, Jeon T, Sedmak G, Pletikos M, Vasung L, Xu X, Yarowsky P, Richards LJ, Kostovic I, Sestan N, Mori S. (2012) Coupling Diffusion Imaging with Histological and Gene Expression Analysis to Examine the Dynamics of Cortical Areas across the Fetal Period of Human Brain Development. Cereb Cortex. 2013 Nov;23(11):2620-31. doi: 10.1093/cercor/bhs241
  • Petanjek Z, Kostović I.(2012) Epigenetic regulation of fetal brain development and neurocognitive outcome. Proc Natl Acad Sci U S A.;109(28):11062-3. doi: 10.1073/pnas.1208085109.
  • Kwan KY, Lam MM, Johnson MB, Dube U, Shim S, Rašin MR, Sousa AM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostović I, Judaš M, Sestan N. (2012) Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell. 11;149(4):899-911. doi: 10.1016/j.cell.2012.02.060.
  • Kostović I, Jovanov-Milošević N, Radoš M, Sedmak G, Benjak V, Kostović-Srzentić M, Vasung L, Culjat M, Radoš M, Hüppi P, Judaš M. (2012) Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches. Brain Struct Funct. 2014 Jan;219(1):231-53. doi: 10.1007/s00429-012-0496-0
  • Bregant T, Rados M, Vasung L, Derganc M, Evans AC, Neubauer D, Kostovic I.(2013) Region-specific reduction in brain volume in young adults with perinatal hypoxic-ischaemic encephalopathy. Eur J Paediatr Neurol. 2013 Nov;17(6):608-14. doi: 10.1016/j.ejpn.2013.05.005.
  • Judaš M, Sedmak G, Kostović I.(2013) The significance of the subplate for evolution and developmental plasticity of the human brain. Front Hum Neurosci. 2013 Aug 2;7:423. doi: 10.3389/fnhum.2013.00423. eCollection 2013.
  • Pogledic I, Kostovic I, Fallet-Bianco C, Adle-Biassette H, Gressen P, Verney C (2014) Involvement of the subplate zone in preterm infants with periventricular white matter injury. Brain Pathol. 2014 Mar;24(2):128-41. doi: 10.1111/bpa.12096. Epub 2014 Feb 18.
  • Kostović I, Kostović-Srzentić M, Benjak V, Jovanov-Milošević N, Radoš M. (2014) Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates. Front Neurol. 2014 Jul 29;5:139. doi: 10.3389/fneur.2014.00139. eCollection 2014
  • Jovanov Milošević N, Judaš M, Aronica E, Kostovic I.(2014) Neural ECM in laminar organization and connectivity development in healthy and diseased human brain. Prog Brain Res. 2014;214:159-78.
  • Slade N, Zorić A, Horvat B, Vukšić M, Kostović I, Poljak L. Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation. Immunobiology. 2015 Jan;220(1):48-53. doi: 10.1016/j.imbio.2014.09.003. Epub 2014 Sep 16.
  • Kostović I, Sedmak G, Vukšić M, Judaš M.(2015) The Relevance of Human Fetal Subplate Zone for Developmental Neuropathology of Neuronal Migration Disorders and Cortical Dysplasia. CNS Neurosci Ther. 2015 Feb;21(2):74-82. doi: 10.1111/cns.12333
  • Vasung L, Lepage C, Radoš M, Pletikos M, Goldman JS, Richiardi J, Raguž M, Fischi-Gómez E, Karama S, Huppi PS, Evans AC, Kostovic I (2016) Quantitative and Qualitative Analysis of Transient Fetal Compartments during Prenatal Human Brain Development. Front Neuroanat. 2016 Feb 24;10:11.
  • Duque A, Krsnik Z, Kostović I, Rakic P. Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9892-7

SELECTED BOOK CHAPTERS:

  1. Štampalija A, Kostović I (1981) The laminar organization of the superior colliculus (SC) in the human fetus. In: Huber A, Klein D (eds) Neurogenetics and Neuroophthalmology. Amsterdam: Elsevier/North-Holland Biomedical Press, pp. 107-110.
  2. Kostović I (1990) Zentralnervensystem. In: Hinrichsen KV (ed) Humanembryologie - Lehrbuch und Atlas der vorgeburtlichen Entwicklung des Menschen. Berlin-Heidelberg-New York: Springer-Verlag, pp. 381-448.
  3. Kostović I, Judaš M (1992) Mass Killing and Genocide in Croatia 1991/92: A Book of Evidence. Zagreb: Hrvatska Sveučilišna Naklada.
  4. Kostović I, Petanjek Z, Delalle I, Judaš M (1992) Developmental reorganization of the human association cortex during the perinatal and postnatal life. In: Kostović I, Knežević S, Spillich G, Wisniewski J (eds): Neurodevelopment, Aging, and Cognition. Boston: Birkhäuser, pp. 3-17.
  5. Kostović I, Judaš M (1993) “Wer Glück hatte, wurde nachts durch Klopfen an der Tür geweckt”. Zusammenfassender Bericht über Kriegsverbrechen, Verbrechen gegen die Menschlichkeit, Genozid und “Ethnische Säuberung” im Krieg gegen Kroatien 1991/92. In: Zülch T (ed.) Ethnische Säuberung – Völkermord für Grossserbien. Eine Dokumentation der Gesselschaft für bedrohte Völker. Hamburg-Zürich: Sammlung Luchterhand, Flugschrift 5, Luchterhand Literatur-Verlag, pp. 47-55.
  6. Kostović I, Judaš M (1994) Prenatal and perinatal development of the human cerebral cortex. In: Kurjak A, Chervenak FA (eds) The Fetus as a Patient: Advances in Diagnosis and Therapy. New York-London: The Parthenon Publishing Group, pp. 35-55.
  7. Kostović I, Judaš M (1995) Prenatal development of the cerebral cortex. In: Chervenak FA, Kurjak A, Comstock CH (eds) Ultrasound and the Fetal Brain (Progress in Obstetric and Gynecological Sonography Series). New York-London: The Parthenon Publishing Group, pp. 1-26.
  8. Kostović I, editor (2003) Guidance Cues in the Developing Brain (Progress in Molecular and Subcellular Biology 32). Berlin: Springer-Verlag, 145 pp.
  9. Kostović I, Judaš M (2008) Maduracíon de las conexiones cerebrales y la conducta fetal. In: Carrera J.M, Kurjak A. (eds) Conducta fetal. Estudio ecográfico de la neurogia fetal. Barcelona: Elsevier Masson, pp 21-27
  10. Kostović, Ivica; Čuljat, Marko; Judaš, Miloš. (2008) Structure and Plasticity : Relation to Suicidality in Lowering Suicide Risk in Returning Troops : Wounds of War. Wiederhold, Brenda K. (ed.).
  11. Amsterdam : IOS Press, 2008. pp. 23-32.
  12. Kostović, Ivica; Judaš, Miloš (2009) Maturation of Cerebral Connections and Fetal Behavior in Fetal Neurology Pooh, Ritsuko K ; Kurjak, Asim (eds..).New Delhi : Jaypee Brothers Medical Publishers, pp. 440-452.
  13. Kostović I., Judaš M. (2009) Early Development of Neuronal Circuitry of the Human Prefrontal Cortex in The Cognitive Neurosciences, 4th Edition, Cambridge-London MIT Press, 2009. Pp. 29-48.
  14. Kostovic I; Judas M (2015) Embryonic and Fetal Development of the Human Cerebral Cortex in Brain Mapping: An Encyclopedic Reference; Volume 2: Anatomy and Physiology, Systems. Elsevier 2015. Pp 167-175

IVICA KOSTOVIĆ: MAIN SCIENTIFIC ACHIEVEMENTS

The major contributions of Professor Ivica Kostović to the developmental neuroscience can be summarized as follows:

  1. The discovery of early presence of synapses in the human neocortex at 8th postconceptional week at the transition from embryonic to fetal period. This finding of bilaminar (above and below cortical plate) distribution of earliest synapses in the human neocortex marks an important period when there is “beginning of human life as cortical being”.
  2. The first description of early synaptogenesis in the entorhinal cortex and hippocampal formation – it was demonstrated that these cortical structures, crucial for cognitive functions, learning and memory, develop functional contacts already during the third month of gestation, significantly before the first interaction of developing cortex with the external environment.
  3. The discovery of the transient fetal subplate zone in humans as a key compartment for the development of cerebral cortical pathways (“waiting compartment”) and cortical circuitry. Subsequent research has demonstrated a crucial role of the subplate zone in the topographically proper and sequential in-growth of cortical afferents, the establishment of cortical maps and its modular organization, and in the plasticity and recovery of cortical function after the perinatal lesion, especially in prematurely born infants.
  4. The discovery of anatomical substrate of connection of sensory thalamus and cortex (pioneering studies of thalamocortical projection to visual auditory, somatosensory and frontal cortex) which is established in the human foetus around the 24th post-ovulatory week. This fact, that there is connection between sensory periphery and cerebral cortex in the human fetus, has been used by the U.S.A. Supreme Court as supporting evidence for the law forbidding the abortion after the 6th month of gestation. It is also used by anaesthesiologists, who (knowing this) do not any more perform surgery on prematurely born babies without the anaesthesia, because preterm babies do feel the pain! Recently the anatomical substrate of thalamocortical connectivity became very important for interpretation of preconscious state, resting MR functional activity and interpretation of functional events in the human preterm brain.
  5. The demonstration that the overproduction of cortical dendritic spines and synapses reaches its peak during the third year of postnatal life (at the onset of cognitive functions) and returns to normal adult values during the third decade. In addition, cortical pyramidal neurons display a very protracted histochemical and morphological maturation extending up to 26 years of postnatal life. The extensive documentation of these two developmental phenomena is significant for explaining the protracted period of human cortical plasticity and reorganization during the first two decades of socialization, education and cognitive development and maturation.
  6. Salient new findings about origin, developmental expansion, reorganisation, postnatal fate and diagnostic significance of the enigmatic subplate zone. Based on experimental monkey material from Dr. Rakic and human material from Zagreb Neuroembryological Collection, a novel explanation of secondary expansion in primate brain was presented. Combination of histological and MR study, revealed new data on perinatal reorganisation of subplate and postnatal persistence related to cortical associative pathways. The normative data on development of cortical connections and transient layers were translated in long-term study of perinatal brain lesions resulting in a new interpretation of structural substrate of cognitive, sensory and motor disorders. This correlated MR-histological data help in diagnostic work, planning of protective measurements and habilitation treatment for preterm babies and perinatally damaged babies.
  7. Contribution to the progress of brain research in Europe: Foundation of Croatian Institute for Brain Research (CIBR), which became Centre of Excellence for Basic, Clinical and Translational Neuroscience and contributed to the development of neuroscience in Croatia as a European country. Long-term research program of CIBR focused on development of human brain and translational neuroscience started in 1990, even before official declaration of Decade of The Brain in Europe. The development of CIBR was associated with intensive cooperation with Clinical neuroscience and development of PhD Neuroscience program. CIBR became a central place of activity of Croatian Society for Neuroscience, a member of FENS and IBRO, and also central place for organisation of international symposiums. The most important scientific database of CIBR is Zagreb Neuroembryological Collection, which is the life achievement of Dr. Kostovic. It is internationally recognised, resulted in numerous publications in high ranking journals, and recently available on-line http://www.zagrebbraincollection.hr/.

 

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