Voditelji:
Prof.dr.sc. Miloš Judaš
Redoviti profesor neuroznanosti i anatomije
Hrvatski institut za istraživanje mozga
Šalata 12, 10 000 Zagreb, Hrvatska
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Prof.dr.sc. Nenad Šestan
Redoviti profesor neurobiologije, komparativne medicine, genetice i psihijatrije
Department of Neurobiology
School of Medicine Yale University
333 Cedar Street, New Haven, CT, USA
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Suradnici:
Doc.dr.sc. Goran Sedmak
Hrvatski institut za istraživanje mozga
Doc.dr.sc. Željka Krsnik
Hrvatski institut za istraživanje mozga
Mihovil Pletikos, dr.med.
School of Medicine Yale University
Ana Jagušt
Hrvatski institut za istraživanje mozga
Istraživanja u našem laboratoriju usmjerena su na otkrivanje koko promjene u ekspresiji gena utječu na strukturni i funkcionalni razvoj ljudskog mozga. U ovim nastojanjima, prije svega smo usredotočeni na prolazne fetalne strukture i s njima povezane stanične elemente. Nadalje, istražujemo i kako na ove procese utječju evolucijske promjene u nadi da ćemo barem dijelomično odgovoriti na pitanje „Što nas čini ljudima“. U ovu svrhu u našem laboratoriju koristimo slijedeće metodologije: analizu mikropostroja, PCR, qRT-PCR ,itd.
Znanstveni interesi:
Morfološki i funkcionlni razvoj neurona u regijama bitnima za govor.
Promjene u ekspresiji gena u regijama bitnima za govor.
Klasifikacija subpopulacija neurona u subplate zoni čovjeka.
Praćenje molekularnog sazrijevanja prolaznih fetalnih zona.
Klasifikacija neurona bijele tvari na temelju molekularnih biljega.
Trenutačni projekti:
Miloš Judaš: Development of cell-type specific expression of human transcriptome in language- and mirror neuron-system related cortical network (CSF reserach grant)
Heads:
Professor Miloš Judaš
Professor of Neuroscience and Anatomy
Croatian Institute for Brain Research
Šalata 12, 10 000 Zagreb, Croatia
This email address is being protected from spambots. You need JavaScript enabled to view it.
Professor Nenad Šestan
Professor of Neurobiology, Comparative Medicine, Genetics and Psychiatry
Department of Neurobiology
School of Medicine Yale University
333 Cedar Street, New Haven, CT, USA
This email address is being protected from spambots. You need JavaScript enabled to view it.
Associates:
Assistant Professor Goran Sedmak
Croatian Institute for Brain Research
Assistant Professor Željka Krsnik
Croatian Institute for Brain Research
Mihovil Pletikos, MD
School of Medicine Yale University
Ana Jagušt
Croatian Institute for Brain Research
Research in our laboratory invstigates how changes in gene expression influence structural and functional development of the human brain. In pursuit of this goal we are focused on the transient fetal zones and related cellular structures. Furthermore, we explore evolutionary changes in order to understand the importance of above mentioned structure for “what makes us human”. To explore these problems we use varous molelucar tecniques such as; microarray analysis, PCR, qRT-PCR, etc.
Scientific scope:
Functional and morphological development of neurons in language related areas.
Changes in gene expression during development in language related areas.
Classification of neuronal subpopulations in the human subplate.
Molecular maturation of transient fetal structures.
Molecular classification of interstitial neurons of white matter.
Current projects.
Miloš Judaš: Development of cell-type specific expression of human transcriptome in language- and mirror neuron-system related cortical network (CSF reserach grant)
- Huang, H., Jeon, T., Sedmak, G., Pletikos, M., Vasung, L., Xu, X. M., Yarowsky, P., Richards, L. J., Kostovic, I., Sestan, N. and Mori, S.; (2013); "Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development." Cerebral Cortex 23(11): 2620-2631.
- Judas, M., Sedmak, G. and Kostovic, I.; (2013); "The significance of the subplate for evolution and developmental plasticity of the human brain." Frontiers in Human Neuroscience 7: 9.
- Judas, M., Sedmak, G., Pletikos, M. and Jovanov-Milosevic, N.; (2010); "Populations of subplate and interstitial neurons in fetal and adult human telencephalon." Journal of Anatomy 217(4): 381-399.
- Ouyang, A., Jeon, T., Sunkin, S. M., Pletikos, M., Sedmak, G., Sestan, N., Lein, E. S. and Huang, H.; (2015); "Spatial mapping of structural and connectional imaging data for the developing human brain with diffusion tensor imaging." Methods 73: 27-37.
- Pletikos, M., Sousa, A. M. M., Sedmak, G., Meyer, K. A., Zhu, Y., Cheng, F., Li, M. F., Kawasawa, Y. I. and Sestan, N.; (2014); "Temporal specification and bilaterality of human neocortical topographic gene expression." Neuron 81(2): 321-332.
- Sedmak G., Jovanov-Milošević N., Puskarjov M., Ulamec M., Krušlin B., Kaila K., Judaš M.; (2015); “Developmental expression patterns of KCC2 and functionally associated molecules in the human brain.” Cerebral Cortex in press.
